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T cells proteins under electron microscope

Your questions answered: Methotrexate

Methotrexate is a type of disease-modifying anti-rheumatic drug (DMARD) often prescribed for treating arthritis. It’s used to reduce activity of the immune system in people who have certain types of arthritis and related conditions. 

About methotrexate

Read Madeleine's story: "I should be chasing my grandkids, not my treatment."

Diagnosed at just 5 years old, Madeleine has had both hips replaced along with both knees. She jokes that her medical team describes her as “the bionic woman”. 

Read Madeleine's story

Stress and arthritis: What is the connection?

Stress can worsen autoimmune inflammatory arthritis, such as rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis. In conditions like these, the immune system, the body's natural defence system, is out of balance and can attack your joints, spine, and sometimes other organs too. Find out how.

Stress and arthritis

Arthritis UK Christmas shop

Support life-changing research and vital services for people with arthritis this Christmas. Choose from a range of traditional, religious and cute designs, buy online and get fast delivery. Wrapping paper also available. 

Buy Christmas cards

Arthritis UK news

Whatever form of arthritis you are managing, flare-ups can be debilitating and difficult to deal with. Joint pain, swelling, fatigue and stiffness may strike suddenly and without any apparent trigger. 

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When people with arthritis experience pain, it can feel instinctive to rest. However, this may not always be the best approach. Evidence-based exercise programmes, like ESCAPE-Pain tell us why. 

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Chronic pain affects all aspects of our lives, including our mental health. We funded the De-Stress project to learn more about how we might tackle pain-related distress and explore our findings. 

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Gifts in Wills fund a third of our work, providing support and hope to so many. By considering a gift in your Will, you can help ensure that future generations won’t have to face the impact of arthritis. 

Leave a gift in your Will

A quick, accurate diagnosis is essential for people with arthritis - and so are personalised treatments that tackle arthritis before it does too much damage to the joints. That’s why we fund research that focuses on these priority areas.

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Researchers have found that eating more fruit and vegetables and eating red meat less often reduces your risk of developing rheumatoid arthritis. Plus, a diet high in processed meats and low in fibre makes our immune system age more quickly.

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Created specially for people living with arthritis, every edition of Inspire magazine is packed with expert, in-depth articles and features, covering what matters most to you — all for just £3 a month. 

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